The essential adaptors of innate immune signaling

Integration of Innate Immune Signaling.

The last decades of research in innate immunology have revealed a multitude of sensing receptors that evaluate the presence of microorganisms or cellular damage in tissues. In the context of a complex tissue, many such sensing events occur simultaneously. Thus, the downstream pathways need to be integrated to launch an appropriate cellular response, to tailor the magnitude of the reaction to th...

Signaling Organelles of the Innate Immune System

There are at least five families of microbe-detection receptors that function to detect and eradicate potentially infectious microorganisms that enter multicellular eukaryotes. While a multitude of proteins regulating innate immune signal transduction have already been defined, continuous genetic screening for regulators of innate immunity may not yield as significant insight into the operation...

Signaling in the innate immune response.

Innate immune signaling in the myelodysplastic syndromes.

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematologic malignancies characterized by cytopenias caused by ineffective hematopoiesis and propensity to progress to acute myeloid leukemia. Innate immunity provides immediate protection against pathogens by coordinating activation of signaling pathways in immune cells. Given the prominent role of the innate immune pathway in regulating...

Adaptors and Molecular Scaffolds in Immune Cell Signaling

containing leukocyte protein of 76 kDa), BLNK (B cell linker protein)/SLP-65 (SH2 domain–containing leuko-cyte protein of 65 kDa), FYB (Fyn T-binding protein)/ SLAP (SLP-76-associated protein), SKAP55 (Src kinase– associated protein of 55 kDa), and the 3BP2 protein. Introduction Positive Adaptors in T Cells The antigen receptors on T and B lymphocytes (TCR and Following their activation by TCR ...